SEA to win-160
TLDR: San Francisco makes its first trip into an opponent's stadium this season, to the building where it lost 41-6 in January, and it comes without Bosa and a starting safety.
Point
- Last 2 meetings
Seattle won both games last January, 13-3 at Levi's and 41-6 in the Divisional Round at Lumen, holding San Francisco to 9 points over 8 quarters.
- 49ers pass rush
Nick Bosa is ruled out with knee and calf injuries, and Mykel Williams is only questionable, so Darnold should get cleaner pockets than a 4-0 defense usually allows.
- First true road game
San Francisco opened at a neutral site in Melbourne and then played 3 straight at Levi's, so Lumen is the 1st opponent's stadium it has played in this year.
- 49ers secondary
Safety Marques Sigle is out and slot corner Upton Stout is questionable after missing practice, which thins the coverage Smith-Njigba and Kupp will work against.
Counterpoint
- Seattle discipline
Seattle set a franchise record last week with 150 penalty yards, including 7 personal fouls, and extra free yards keep a short-handed 49ers offense on the field.
- Seattle backfield
Emanuel Wilson makes his 2nd start for Seattle with Charbonnet out and Price on IR, and his backup George Holani is questionable with a rib injury.
Neutral
- Weather
Sunny and dry at open-air Lumen Field with a high near 60, so neither offense has to change its game plan.
- Rest and travel
Both teams played at home on Sunday, October 4, and the 49ers have a short flight up the coast, so neither side has a rest edge.