Who is favored in Colorado Buffaloes at Baylor Bears?

Baylor Bears are favored on the moneyline.

Who is predicted to win Colorado Buffaloes at Baylor Bears?

Our pick is Colorado Buffaloes. Colorado's price is still anchored to a 41-7 road blowout that happened days before this line went up, not to the offense that hung 52 on Weber State or won at Georgia Tech on a walk-off. As the week goes on and books weigh that Baylor's best win came against an FCS team, expect Colorado's number to shorten.

Colorado Buffaloes at Baylor Bears

Sep 26, 2026·11:00 AM CT·Waco, TX

By JR·1 min read

COLO(2-1)

BAY(2-1)

AT

11:00 AM CT

TLDR: Colorado has looked unstoppable and unwatchable in back-to-back weeks, and Baylor's Big 12 opener gets whichever version shows up in Waco.

SAT SEP 26, 11:00 AM CT

Spread

WIN

Total

Colorado

(2-1)

LWWLL

Baylor

(2-1)

WWLLL

Kickoff85°

Colorado arrives 2-1 after the best and worst versions of itself showed up in consecutive weeks, while Baylor is 1-1 off a 1-point loss to Auburn and a lopsided win over an FCS team. Neither club has faced anything resembling this level of competition yet, which makes the Big 12 opener in Waco the first real data point for both.

Colorado

Won road opener at Georgia Tech on a walk-off
Lewis threw for 366 yards, 4 TDs vs Weber State
Blown out 41-7 at Northwestern, 2 INTs from Lewis
Defense has already been gashed for 41 in a game

Baylor

Blew out Prairie View A&M 44-3 at home
Lost the opener to Auburn by just 1 point
Best win of the year came against an FCS team
New DC's unit already gave up 17 to Auburn

Julian Lewis has been the swing factor for Colorado all September, torching Weber State for 366 yards and 4 touchdowns one week before throwing 2 interceptions in a 41-7 loss at Northwestern. Baylor counters with DJ Lagway, the five-star transfer from Florida, making his first true road-atmosphere test as a Bear, and this Big 12 opener at McLane Stadium is the first real measuring stick for either quarterback against conference-caliber competition.

Baylor's defense under new coordinator Joe Klanderman held up well enough to nearly steal the opener from Auburn, losing by a single point, before it faced nothing tougher than an FCS offense the following week. Colorado's own defense is the bigger question mark after Northwestern hung 41 on it, and the early number reads like a market still deciding which Buffaloes team is real.

Both offenses have flashed real ceiling and real fragility through 2 starts apiece, which makes this opener less about the record on paper and more about which flaws actually show up on Saturday.

Colorado has already played 2 of its first 3 games on the road this month, splitting them, so a third straight road trip to a hostile Big 12 building is not new territory even if the result at Northwestern was ugly. Baylor gets the benefit of a home crowd for a game that will say more about Klanderman's defense than the 44-3 laugher over Prairie View A&M did.

Neither program has settled who it is yet, and a Big 12 opener with this much swing in both team's tape usually turns on whichever defense stops bleeding chunk plays first.

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