The Sixers' schedule is the bigger factor. Philadelphia hosts Milwaukee on Saturday, the night before this one, so Sunday is the 2nd half of a back-to-back. LeBron James was questionable for the Bucks game with what the team called low back and sciatica management, and reports had Philly considering sitting the 41-year-old for the first leg. Whatever happens Saturday decides what Sunday looks like: whether LeBron plays this one, how much the bench gets run, and whether a 3rd straight comeback has worn out legs that are already short a few big men.
For Detroit, it comes down to the middle. Without Duren the Pistons lose their main rebounder and rim presence. That hurts a lot less against a Sixers frontcourt that's been held together with tape, and Philadelphia may not be able to punish his absence. If Thompson's ankle keeps him out too, Detroit also loses its best perimeter defender. That could matter against a Sixers team that has made a habit of taking over second halves.
Detroit has the cleaner schedule. The Pistons played in Miami on Friday and get Saturday off before tipping at 7:30 PM ET on Sunday, October 25, while Philadelphia comes off a game the night before. Both teams have won 2 straight as of Saturday morning, and only the Sixers can change that before tip. Whoever is healthier on Sunday will have the upper hand, and right now nobody knows who that is.
Wait for the Saturday injury reports from both teams and see how many minutes Philly's starters play against the Bucks. That will say more about this game than either 2-0 record does.