By implied win totals this is the most lopsided game of Week 1: the Chargers at 9.6 wins host a Cardinals team priced at 4.5 — a 5.1-win gulf. Arizona's number is 2nd-worst in the league, above only Miami's 4.4, and its 0.7% NFC price is last in the conference outright.
Los Angeles' market season is genuinely interesting: 9.5% to win the AFC is 3rd, behind only Baltimore and Buffalo and ahead of both Kansas City and the Super Bowl runner-up Patriots. Justin Herbert's 6.5% MVP price (8th) and Omarion Hampton's 11% on the fantasy RB board fill out a profile the market keeps nudging upward.
The trap in a 5-win mismatch is that it's priced into everything already. The Chargers gain almost nothing in the futures markets by handling Arizona at home — but a loss would be the single most repricing result of the entire week, anywhere on the board.
For Arizona there's a cleaner framing: 4.5 expected wins means the market prices the Cardinals to be competitive in roughly a quarter of their games. The season, as traded, is about finding those 4 or 5 — and SoFi in Week 1 is emphatically not projected as one of them.